apoptosis induction — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2051	SKLB4771	FLT3-IN-1,FLT3-IN-1	FLT
	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.		FLT
T11209	EOAI3402143		DUB
	EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.		DUB
T21017	5'-Amino-5'-deoxyadenosine	5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo	Apoptosis , Adenosine Receptor
	5'-Amino-5'-deoxyadenosine (NH2dAdo) is an adenosine kinase inhibitor targeting malignant tumors of the inert lymphatic system with antitumor and anticancer effects.The anticancer mechanism of 5'-Amino-5'-deoxyadenosine ...		Apoptosis , Adenosine Receptor
TMS0484	Episyringaresinol 4'-O-β-D-glncopyranoside	(-)-Syringaresinol 4-O-β-D-glucopyranosi	Others
	Episyringaresinol 4'-O-β-D-glncopyranoside ((-)-Syringaresinol 4-O-β-D-glucopyranosi) inhibits the proliferation of human promyelocytic HL-6 cells through G(1) arrest and induction of apoptosis, may be a potential chemot...		Others
T6S0234	Toosendanin		Others
	1. Toosendanin possesses hepatotoxicity. 2. Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells. 3. Toosendanin i...		Others
TJS0487	(-)-Syringaresinol	DL-Syringaresinol,Lirioresinol b	Others
	(-)-Syringaresinol (DL-Syringaresinol) is derived from the stems of Annona Montana. (-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis and posses...		Others
T1535	Sodium 4-phenylbutyrate	Sodium Phenylbutyrate,Buphenyl,TriButyrate	Apoptosis , HDAC , Autophagy
	Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, inc...		Apoptosis , HDAC , Autophagy
T5S1607	Morusin	Mulberrochromene	NF-κB , Antibacterial , STAT
	1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti...		NF-κB , Antibacterial , STAT
T6891	MK-4101		Apoptosis , Hedgehog/Smoothened , Smo
	MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells.		Apoptosis , Hedgehog/Smoothened , Smo
T2S0886	Terrestrosin D		Apoptosis , Others
	Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of action...		Apoptosis , Others
TN1461	(-)-Butin	Butin	Akt , PI3K , Nrf2
	(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SO...		Akt , PI3K , Nrf2
T8969	API-1	NSC177223	Akt
	API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .		Akt
T6017	Linsitinib	OSI-906	IGF-1R
	OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, whic...		IGF-1R
T5S1285	(+)-(3R,8S)-Falcarindiol	Falcarindiol	Others
	1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a nov...		Others
T1608	ADH-1 trifluoroacetate	Exherin trifluoroacetate	Dehydrogenase
	ADH-1 trifluoroacetate (Exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-c...		Dehydrogenase
T35528L	TD52 dihydrochloride	TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali...		Others
T10352	APTO-253	LOR-253,LT-253	Apoptosis , c-Myc , KLF
	APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the K...		Apoptosis , c-Myc , KLF
T3351	Onatasertib	CC223,CC 223,CC-223	Apoptosis , c-Fms , DNA-PK , FLT , PI3K , mTOR
	Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor ce...		Apoptosis , c-Fms , DNA-PK , FLT , PI3K , mTOR
TNU0630	2'-O-Methyl-5-iodouridine	5-Iodo-2'-O-methyluridine
	2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses a broad spectrum of antitumor activity. The anticancer mechani...
T3124	Carbendazim	Bavistin,Carbendazole,Mercarzole	Antifungal
	Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec...		Antifungal